Sažetak
Stres može značajno uticati na kvalitet života pacijenata sa malignim bolestima i na njihovo iskustvo u vezi sa primenjenom terapijom. Budući da je radioterapija jedan od najvažnijih terapijskih pristupa u lečenju malignih bolesti, neophodno je da se razume njen uticaj na psihoemocionalno zdravlje kako bi se mogle osmisliti sveobuhvatne strategije za očuvanje i poboljšanje psihičkog i fizičkog zdravlja pacijenata.
U ovom istraživanju ispitivali su se efekti radioterapije na psihoemoconalne karakteristike pacijenata sa malignim bolestima. Takođe, analizirani su efekti primene radioterapije kombinovane sa hormonskom terapijom, biološkom terapijom i hemoterapijom. Dobijeni rezultati ukazuju na to da, uprkos prisustvu stresa kod pacijenata koji primaju radioterapiju, postoje promene u njihovoj emocionalnoj kompetenciji, reakcijama na stres, depresiji i intrinzičnoj religioznosti slične onima koje doživljavaju zdrave osobe. Pacijenti podvrgnuti radioterapiji imali su značajno niži rezultat na Indeksu interpersonalne reaktivnosti (engl. interpersonal reactivity index ‒ IRI), na Skali altruizma i na Bekovom indeksu anksioznosti (engl. Beck anxiety inventory−BAI) u poređenju sa zdravim ispitanicima.
Porast nuspojava kod pacijenata koji primaju radioterapiju ukazuje na traženje spoljašnjih opravdanja za postojeću bolest. Uvođenje hormonske terapije značajno je povećalo stepen religioznosti i poboljšalo prihvatanje bolesti u emocionalnom smislu. Nasuprot tome, biološka terapija je dovela do smanjenja stepena religioznosti verovatno zbog nepoznavanja mogućih ishoda i posledica primene ove metode lečenja. Važno je pomenuti da hemoterapija nije značajno promenila psihoemocionalne karakteristike izazvane radioterapijom, što može učvrstiti shvatanje da poznavanje terapijskih modaliteta može podsteći emocionalnu otpornost i osećaj kontrole kod pacijenata. U zaključku ovog istraživanja naglašena je važnost očuvanja psihoemocionalnog blagostanja za lečenje i sveobuhvatnu negu pacijenata sa malignim bolestima koji su bili podvrgnuti radioterapiji.
Ključne reči
Reference
Alica A, Cericb H, Habibovic S. The Connections of Empathy and Life Styles among Bosnian Students. Procedia-Social and Behavioral Sciences 2015;205:457-62. [CrossRef]
Arina A, Gutiontov SI, Weichselbaum RR. Radiotherapy and Immunotherapy for Cancer: From "Systemic" to "Multisite". Clin Cancer Res 2020;26:2777-82. [CrossRef][PubMed]
Beadle JN, Brown V, Keady B, Tranel D, Paradiso S. Trait empathy as a predictor of individual differences in perceived loneliness. Psychol Rep 2012;110:3-15. [CrossRef][PubMed]
Belgioia L, Desideri I, Errico A, Franzese C, Daidone A, Marino L, et al. Safety and efficacy of combined radiotherapy, immunotherapy and targeted agents in elderly patients: A literature review. Crit Rev Oncol Hematol 2019;133:163-70. [CrossRef][PubMed]
Brunner TB. The rationale of combined radiotherapy and chemotherapy - Joint action of Castor and Pollux. Best Pract Res Clin Gastroenterol 2016;30:515-28. [CrossRef][PubMed]
Goldsworthy S, Palmer S, Latour JM, McNair H, Cramp M. A systematic review of effectiveness of interventions applicable to radiotherapy that are administered to improve patient comfort, increase patient compliance, and reduce patient distress or anxiety. Radiography (Lond) 2020;26:314-24. [CrossRef][PubMed]
Li W, Gan C, Zuo H, Yin X, Jing Y, Pang L, et al. Psychological distress as risk factor for the efficacy of whole-brain radiotherapy in brain metastasis patients. Future Oncol 2023;19:49-60. [CrossRef][PubMed]
Lu N, Qin T, Hu W. Impact of changes in psychological resilience during treatment with intensity-modulated radiotherapy on nasopharyngeal carcinoma patients: a prospective study. Ann Palliat Med 2022;11:123-134. [CrossRef][PubMed]
Lu Y, Hua J, Yan F, Jiang C, Piao Y, Ye Z, et al. Combined radiotherapy and chemotherapy versus radiotherapy alone in elderly patients with nasopharyngeal carcinoma: A SEER population-based study. Medicine (Baltimore) 2021;100:e26629. [CrossRef][PubMed]
Man KH, Law HK, Tam SY. Psychosocial needs of post-radiotherapy cancer survivors and their direct caregivers - a systematic review. Front Oncol 2023;13:1246844. [CrossRef][PubMed]
Muszalik M, Repka I, Puto G, Kowal-Skałka J, Kędziora-Kornatowska K. Assessment of Functional Status and Quality of Life of Elderly Patients Undergoing Radiotherapy and Radiotherapy Combined with Chemotherapy - A Cross-Sectional Study. Clin Interv Aging 2021;16:9-18. [CrossRef][PubMed]
Opalach C, Romaszko J, Jaracz M, Kuchta R, Borkowska A, Buciński A. Coping Styles and Alcohol Dependence among Homeless People. PLoS One 2016;11:e0162381. [CrossRef][PubMed]
Park S, Sato Y, Takita Y, Tamura N, Ninomiya A, Kosugi T, et al. Mindfulness-Based Cognitive Therapy for Psychological Distress, Fear of Cancer Recurrence, Fatigue, Spiritual Well-Being, and Quality of Life in Patients With Breast Cancer-A Randomized Controlled Trial. J Pain Symptom Manage 2020;60:381-9. [CrossRef][PubMed]
Plummer C, Steingart RM, Jurczak W, Iakobishvili Z, Lyon AR, Plastaras JP, et al. Treatment specific toxicities: Hormones, antihormones, radiation therapy. Semin Oncol 2019;46:414-20. [CrossRef][PubMed]
Pointer KB, Pitroda SP, Weichselbaum RR. Radiotherapy and immunotherapy: open questions and future strategies. Trends Cancer 2022;8:9-20. [CrossRef][PubMed]
Raboteg-Saric Z, Saric J, Zajc M. A study of values among adolescents: Assessing terminal and instrumental value systems and orientations. Journal for General Social Issues 2013;6:6-32.
Rolfo C, Sortino G, Smits E, Passiglia F, Bronte G, Castiglia M, et al. Immunotherapy: is a minor god yet in the pantheon of treatments for lung cancer? Expert Rev Anticancer Ther 2014;14:1173-87. [CrossRef][PubMed]
Snider JW 3rd, Mehta M. Principles of radiation therapy. Handb Clin Neurol 2016;134:131-47. [CrossRef][PubMed]
Stiegelis HE, Ranchor AV, Sanderman R. Psychological functioning in cancer patients treated with radiotherapy. Patient Educ Couns 2004;52:131-41. [CrossRef][PubMed]
Taksic V, Mohoric T, Duran M. Emotional skills and competence questionnaire (ESCQ) as a self-report measure of emotional intelligence. Horizons of Psychology 2009;18:7-21. [CrossRef]
Volarevic A, Markovic BS, Jankovic N, Bojic S, Zdravkovic N. Orthodox Catechism affects differences in adolescents’s needs for affiliation and aschievement and alters their sense of purpose in life. Ser J Exp Clin Res 2014;15:33-8. [CrossRef]
Wang C, Chen J, Su L, Hua Y, Ye J, Song X, et al. The psychological status in patients with nasopharyngeal carcinoma during radiotherapy. Eur Arch Otorhinolaryngol 2022;279:1035-42. [CrossRef][PubMed]
Wang Q, Qi F, Song X, Di J, Zhang L, Zhou Y, et al. A prospective longitudinal evaluation of cognition and depression in postoperative patients with high-grade glioma following radiotherapy and chemotherapy. J Cancer Res Ther 2018;14:S1048-S1051. [CrossRef][PubMed]
Xie X, Li H, Wang C, Li W, Xie D, Li M, et al. Effect of modified radical mastectomy combined with neo-adjuvant chemotherapy on postoperative recurrence rate, negative emotion, and life quality of patients with breast cancer. Am J Transl Res 2022;14:460-7.
Yeung JWK. Faith-based intervention, change of religiosity, and abstinence of substance addicts. Braz J Psychiatry 2022;44:46-56. [CrossRef][PubMed]