Abstract
Microneedles are an emerging technology initially developed for minimally invasive cutaneous delivery of therapeutic molecules that were not capable of penetrating the skin. Their use quickly expanded to being used for other applications, such as ocular, gastrointestinal, mucosal, and buccal drug delivery, as well as sampling and sensing the skin interstitial fluid. In particular, dissolvable microneedles (DMN) offer an attractive delivery strategy for drugs and vaccines due to several advantages compared with solid or hollow microneedles. However, the translation of DMN from research laboratories to successful medicinal products is proved to be very challenging and demanding task due to several crucial factors that must be considered. This presentation will provide insight into these factors and an overview of materials and methods used for DMN fabrication along with their feasibility at industrial scale. In addition, safety and regulatory aspects for DMN as potential medicinal products will also be considered.
References
Moore LE, Vucen S, Moore AC. Trends in Drug-and Vaccine-Based Dissolvable Microneedle Materials and Methods of Fabrication. Eur J Pharm Biopharm. 2022; 173, 54-72.
Avcil M, Çelik A. Microneedles in Drug Delivery: Progress and Challenges. Micromachines. 2021; 12(11):1321.
- Autori zadržavaju autorska prava i pružaju časopisu pravo prvog objavljivanja rada i licenciraju ga "Creative Commons Attribution licencom" koja omogućava drugima da dele rad, uz uslov navođenja autorstva i izvornog objavljivanja u ovom časopisu.
- Autori mogu izraditi zasebne, ugovorne aranžmane za neekskluzivnu distribuciju članka objavljenog u časopisu (npr. postavljanje u institucionalni repozitorijum ili objavljivanje u knjizi), uz navođenje da je članak izvorno objavljen u ovom časopisu.
- Autorima je dozvoljeno i podstiču se da postave objavljeni članak onlajn (npr. u institucionalni repozitorijum ili na svoju internet stranicu) pre ili tokom postupka prijave rukopisa, s obzirom da takav postupak može voditi produktivnoj razmeni ideja i ranijoj i većoj citiranosti objavljenog članka (Vidi Efekti otvorenog pristupa).