ISSN: 0004-1963 eISSN: 2217-8767 Journal category: M51 Distinguished National Journal
Scindeks Assistant Scindeks Assistant — A system for serious journals and those aspiring to become one
Vol. 72 No. Suppl. 4 (2022)
Vol. 72 No. Suppl. 4 (2022)

Modeling of dose-response relationships between Pb and Cd levels in testicular and prostate cancer tissues and testosterone levels

Dragana Javorac
University of Belgrade – Faculty of Pharmacy, Department of Toxicology “Akademik Danilo Soldatović”
Katarina Baralić
University of Belgrade – Faculty of Pharmacy, Department of Toxicology „Akademik Danilo Soldatović“
Djurdjica Marić
University of Belgrade – Faculty of Pharmacy, Department of Toxicology „Akademik Danilo Soldatović“
Evica Antonijević Miljaković
University of Belgrade – Faculty of Pharmacy, Department of Toxicology „Akademik Danilo Soldatović“
Milena Andjelković
University of Belgrade – Faculty of Pharmacy, Department of Toxicology „Akademik Danilo Soldatović“; Health center Kosovska Mitrovica
Marijana Ćurčić
University of Belgrade – Faculty of Pharmacy, Department of Toxicology „Akademik Danilo Soldatović“
Danijela Djukić-Ćosić
University of Belgrade – Faculty of Pharmacy, Department of Toxicology „Akademik Danilo Soldatović“
Zorica Bulat
University of Belgrade – Faculty of Pharmacy, Department of Toxicology „Akademik Danilo Soldatović“
Biljana Antonijević
University of Belgrade – Faculty of Pharmacy, Department of Toxicology „Akademik Danilo Soldatović“
Stefan Mandić Rajčević
University of Belgrade – Faculty of Medicine, Institute of Social Medicine and School of Public Health and Health Management
Miodrag Aćimović
Clinical Center of Serbia, Urological Clinic
Aleksandra Buha Djordjević
University of Belgrade – Faculty of Pharmacy, Department of Toxicology „Akademik Danilo Soldatović“
PDF

Published

2022-10-17

Section

Poster presentations session Toxicology

Abstract

Exposure to lead (Pb) and cadmium (Cd) poses risk to human health. It is known that these metals have toxic impact on male reproductive system, leading to physiological disorders and infertility. Limited data indicates the carcinogenic potential of Pb, while Cd has been recognized as carcinogen. Benchmark dose-effect modeling can be applied to data from human, animal and ecotoxicological studies with the aim to obtain Benchmark dose (BMD), starting point in human health risk assessment. The aim of this study was to use Benchmark modeling to determine the dose-effect relationship between Pb and Cd levels in tissues of testicular and prostate cancer patients and serum testosterone levels. The study was conducted at the Clinical Center of Serbia, and included 104 patients with prostate and testicular cancer. Cd and Pb levels (ng/g) were measured by atomic absorption spectrophotometry in isolated healthy surrounding and carcinoma-affected tissues. Testosterone levels (ng/mL) were measured using the chemiluminescence immunoassay (CLIA) method. Dose-effect modeling was performed using PROAST70.1 software with continuous data. The dose dependence was obtained between Cd levels in tumor tissue and testosterone levels (BMD: 0.0024 ng Cd/g, prostate cancer and 0.0038 ng Cd/g, testicular cancer). Dose dependence was obtained between Cd levels in healthy surrounding tissue and testosterone levels (BMD: 0.0092 ng Cd/g). No dose dependence was obtained when modeling Pb levels as a dose. The data from this study indicate a potential link between Cd and testosterone levels, i.e. potential association of Cd exposure with male reproductive health.

References

Autori koji objavljuju u ovom časopisu pristaju na sledeće uslove:

  1. Autori zadržavaju autorska prava i pružaju časopisu pravo prvog objavljivanja rada i licenciraju ga "Creative Commons Attribution licencom" koja omogućava drugima da dele rad, uz uslov navođenja autorstva i izvornog objavljivanja u ovom časopisu.

  2. Autori mogu izraditi zasebne, ugovorne aranžmane za neekskluzivnu distribuciju članka objavljenog u časopisu (npr. postavljanje u institucionalni repozitorijum ili objavljivanje u knjizi), uz navođenje da je članak izvorno objavljen u ovom časopisu.

  3. Autorima je dozvoljeno i podstiču se da postave objavljeni članak onlajn (npr. u institucionalni repozitorijum ili na svoju internet stranicu) pre ili tokom postupka prijave rukopisa, s obzirom da takav postupak može voditi produktivnoj razmeni ideja i ranijoj i većoj citiranosti objavljenog članka (Vidi Efekti otvorenog pristupa).

Downloads

Download data is not yet available.