Abstract
Background. Examination of the intima-media thickness of carotid arteries in COVID-19 infection.
Methods. In 50 patients the thickness of the intimomedial complex (IMT) in the common carotid arteries was measured. The values were compared with the control group in 2006-9. The condition of the lungs was assessed by sonography - mild (0-14) or medium-severe (15-28) covid. IMT thickening risk factors and the value of fibrinogen, IL-6 and CRP were recorded. Two IMT prediction models were formed. The socio-epidemiological model predicts the development of IMT based on epidemiological factors. The second model, apart from these factors, also includes the values of the mentioned biomarkers.
Results. It score 20±6,; IMT right 1.024±0.272; left 0.999±0.224. Control: IMT 0.78±0.27; left 0.79±0.27. The group/control difference is highly significant. Epidemiological model: logit (IMT)= 4.463+(2.021+value for GEN)+ (0. 055x AGE value)+(-3.419x RFvalue)+(-4.447x SM value)+(5.115x HTA value)+ (3.56x DMvalue)+(22.389x LIP value)+(24.206x CVD value)+( 1.449x other value)+(-0.138x IT score value)+(0.19xBMI value). Epidemiological-inflammatory model: logit(IMT)=5.204+(2.545x GEN value)+(0.076x AGE value)+(-6.132x RF value)+(-7.583x SM value)+(8.744x HTA value) + (6.838x DM value)+(25.446x LIP value )+(28.825x CVD value)+(2.487x other value)+(-0.218xIt score value)+( 0.649x BMI value) +(-0.194x fibrinogen value)+(0.894x IL-6 value)+( 0.659x CRP value). Values for both models Exp(B)=4.882; P of sample=0.83; logit=-0.19; OR=23.84; model accuracy for first model 87% and for second 88%; Omnibus test of the first model χ2=34.324;p=0.000; reliability coefficient –2LogLH=56, 854 Omnibus test of the second model χ2=39.774;p=0.000; -2LogLH=51,403.
Conclusion. Aging of blood vessels in COVID-19 can be predicted.
Abbreviations: IMT- thickening of the intima-media complex; GEN - sex; AGE-years; RF - number of risk factors; DM-diabetes; SM-smoking; HTA-hypertension; LIP-lipidemia; CVD- cardiovascular diseases; second - other diseases or condition important for IMT; BMI - body mass index.
Keywords
References
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.