Abstract
Background: To investigate the correlation between the variations of cortisol and insulin-like growth factor 1 (IGF-1) and sex hormone binding globulin (SHBG) levels with insulin resistance and glucolipid metabolism in gestational glucose diabetics.
Methods: The study included 110 pregnant women diagnosed with gestational diabetes mellitus in the GDM group,and 130 healthy pregnant women in the control group. Data collection,examination of relevant indexes,and comparison of differences in indexes between groups were conducted. Pearson correlation analysis was utilized to identify risk variables associated with GDM development,while binary logistic regression was employed to determine risk factors for GDM development.
Results: The GDM group showed significantly greater levels of FPG,HbA1c,FINS,TG,FFA,Lp-PLA2,HOMA-IR,Cortisol,and IGF-1 compared to the control group (P<0.05),but considerably lower levels of SHBG,and HOMA-β. HOMA-IR was found to be positively correlated with FPG,HbA1c,FINS,TG,FFA,Lp-PLA2,Cortisol and IGF-1,whereas,negatively correlated with SHBG. FINS and SHBG were found to be independent protective factors for GDM (OR=0.463,0.801,P<0.05),whereas,HbA1c,TG,FFA,and gestational BMI were found to be independent risk factors for GDM (OR=1.992,4.234,1.990,1.629,P<0.05).
Conclusion: SHBG,IGF-1,and Cortisol are all linked to glucose-lipid metabolism indices,and aberrant serum hormone expression is a major contributor to insulin resistance.
Keywords
Array
Array
Array
Array
Array
References
The published articles will be distributed under the Creative Commons Attribution 4.0 International License (CC BY). It is allowed to copy and redistribute the material in any medium or format, and remix, transform, and build upon it for any purpose, even commercially, as long as appropriate credit is given to the original author(s), a link to the license is provided and it is indicated if changes were made. Users are required to provide full bibliographic description of the original publication (authors, article title, journal title, volume, issue, pages), as well as its DOI code. In electronic publishing, users are also required to link the content with both the original article published in Journal of Medical Biochemistry and the licence used.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.