Abstract
Introduction: it was to demonstrate the impact of traditional Chinese medicine (TCM) matrine combined with omeprazole enteric-coated tablets on the gastric mucosal histopathology, gastric function, inflammatory cytokines, and Helicobacter pylori (H. pylori) eradication in patients with chronic atrophic gastritis (CAG). Materials and Methods: a retrospective collection of case data from 110 patients with CAG admitted to the TCM Department of the hospital was conducted. Patients were rolled into test group (TG, matrine + omeprazole enteric-coated tablets) and control group (CG, omeprazole enteric-coated tablets). The gastric mucosal histopathological scores, serological indicators (interleukin (IL)-2, IL-10, tumor necrosis factor (TNF)-α), gastric function (motilin (MTL), gastrin (GAS), pepsinogen (PG)), H. pylori eradication rate, and clinical efficacy were compared. Results: the degree of glandular atrophy, intestinal metaplasia, dysplasia, and inflammatory activity index in patients of TG post-treatment were lower than CG (P<0.05). Post-treatment, IL-2, IL-10, and TNF-α levels in patients of TG were inferior to CG (P<0.05), and H. pylori eradication rate in patients of TG (87.27%) was inferior to CG (63.64%) (P<0.05). The effective treatment rate in patients of TG post-treatment (92.73%) was higher than CG (78.18%) (P<0.05). Conclusion:matrine plus omeprazole enteric-coated tablets can effectively improve gastric tissue-related symptoms in patients, increase the H. pylori eradication rate, and demonstrate a more significant clinical efficacy in the treatment of CAG compared to monotherapy with Western medicine alone.
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