Vantelesno održavanje života kod teškog kardiogenog šoka izazvanog intoksikacijom diltiazemom
Scindeks Asistent Scindeks Asistent
PDF (engleski)

Kako citirati

1.
Srdanovic I, Kovacevic M, Stefanovic M, Petrovic M, Cankovic M, Velicki L. Vantelesno održavanje života kod teškog kardiogenog šoka izazvanog intoksikacijom diltiazemom . Vojnosanit Pregl [Internet]. 21. April 2021. [citirano 20. Septembar 2026.];76(9). Dostupno na: https://test.aseestant.ceon.rs/index.php/vsp/article/view/15141

Sažetak

Apstrakt

 

Uvod. Le­če­nje kar­di­o­ge­nog šo­ka iza­zva­nog teš­kim tro­va­njem le­ko­vi­ma uvek pred­sta­vlja ve­li­ki iza­zov. U slu­ča­ju po­li­me­di­ka­ment­nog tro­va­nja, is­hod je, upr­kos agre­siv­noj me­di­ka­ment­noj te­ra­pi­ji, ne­pred­vi­div. Pred­lo­že­na je upo­tre­ba ure­đa­ja za van­te­le­sno odr­ža­va­nje ži­vo­ta u ta­kvim slu­ča­je­vi­ma i to sa obe­ća­va­ju­ćim re­zul­ta­ti­ma. Pri­kaz bo­le­sni­ka. Pri­ka­za­li smo bo­le­sni­ka sa teš­kim kar­di­o­ge­nim i di­stri­bu­tiv­nim šo­kom iza­zva­nim su­i­ci­dal­nim tro­va­njem – in­ge­sti­jom dil­ti­a­ze­ma i an­jon­skog sur­fak­tan­ta kod 36-go­diš­nje že­ne. Bo­le­sni­ca je pro­gu­ta­la vi­še of 90 ta­ble­ta dil­ti­a­ze­ma od 90 mg (ukup­na do­za 8,1 gra­ma) i 4 “ku­gli­ce” sred­stva za osve­ža­va­nje to­a­le­ta ko­je sa­dr­ži an­jon­ski sur­fak­tant. To­kom pri­je­ma, si­stem­ski krv­ni pri­ti­sak bio je 65/40 mmHg, fre­kven­ci­ja sr­ča­nog ra­da 45/min, sa zna­ci­ma me­ta­bo­lič­ke aci­do­ze. Bo­le­sni­ca je pod­vrg­nu­ta po­na­vlja­nim ga­strič­nim la­va­ža­ma. Ura­đe­na je hit­na na­dok­na­da vo­lu­me­na, pri­me­njen je kal­ci­jum glu­ko­nat, kao i in­su­lin i va­zo­pre­sor­ni le­ko­vi (do­pa­min i no­ra­dre­na­lin) sa za­ne­mar­lji­vim efek­ti­ma. Usled pro­gre­siv­nog i re­frak­tor­nog kar­di­o­ge­nog šo­ka sa zna­ci­ma mul­ti­or­gan­skog za­ta­je­nja, do­ne­ta je od­lu­ka da se za­poč­ne sa ve­no­ar­te­rij­skom eks­tra­kor­po­ral­nom mem­bran­skom ok­si­ge­na­ci­jom. Ne­po­sred­no na­kon za­po­či­nja­nja van­te­le­sne mem­bran­ske ok­si­ge­na­ci­je, us­po­sta­vlje­na je di­u­re­za. To­kom na­red­nih 36 ča­so­va po­stig­nu­ta je ade­kvat­na per­fu­zi­ja or­ga­na sa kom­plet­nim po­vla­če­njem zna­ko­va mul­ti­or­gan­skog za­ta­je­nja. Na­kon po­nov­nog us­po­sta­vlja­nja funk­ci­je svih or­ga­na, bo­le­sni­ca je pod­vrg­nu­ta de­ka­nu­la­ci­ji na­kon če­ga je, de­se­tog da­na, ot­puš­te­na iz bol­ni­ce u do­brom sta­nju. Za­klju­čak. U slu­ča­je­vi­ma re­frak­tor­nog kar­di­o­ge­nog i di­stri­bu­tiv­nog šo­ka usled tro­va­nja dil­ti­a­ze­mom i osta­lim agen­si­ma, ve­no­ar­te­rij­ska eks­tra­kor­po­ral­na mem­bran­ska ok­si­ge­na­ci­ja mo­že pru­ži­ti do­dat­nu cir­ku­la­tor­nu po­drš­ku i omo­gu­ći­ti do­dat­no vre­me za en­do­ge­no ukla­nja­nje tok­si­na. Ve­no­ar­te­rij­ska eks­tra­kor­po­ral­na mem­bran­ska ok­si­ge­na­ci­ja bi tre­ba­lo da se ko­ri­sti za­jed­no sa op­ti­mal­nom me­di­ka­ment­nom te­ra­pi­jom u ci­lju us­po­sta­vlja­nja per­fu­zi­je krajnjih or­ga­na či­me se pod­sti­če me­ta­bo­li­zam le­ko­va i tok­si­na i nji­ho­va pri­rod­na eli­mi­na­ci­ja.

Ključne reči

kalcijum, blokatori
oksigenacija
pluća, edem
šok, kardiogeni
lečenje, ishod
DOI: 10.2298/VSP170926164S

Reference

REFERENCES

Bronstein AC, Spyker DA, Cantilena LR, Rumack BH, Dart RC. 2011 Annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 29th Annual Report. Clin Toxicol (Phila) 2012; 50(10): 911–1164.

Howarth DM, Dawson AH, Smith AJ, Buckley N, Whyte IM. Cal-cium channel blocking drug overdose: An Australian series. Hum Exp Toxicol 1994; 13(3): 161–6.

DeWitt CR, Waksman JC. Pharmacology, pathophysiology and management of calcium channel blocker and beta-blocker tox-icity. Toxicol Rev 2004; 23(4): 223–38.

Graudins A, Lee HM, Druda D. Calcium channel antagonist and beta-blocker overdose: Antidotes and adjunct therapies. Br J Clin Pharmacol 2016; 81(3): 453–61.

Müller D, Desel H. Common causes of poisoning: Etiology, di-ag¬nosis and treatment. Dtsch Arztebl Int 2013; 110(41): 690–9; quiz 700.

Persson HE, Sjöberg GK, Haines JA, Pronczuk de Garbino J. Poi-son¬ing severity score. Grading of acute poisoning. J Toxi¬col Clin Toxicol 1998; 36(3): 205–13.

St-Onge M, Dubé PA, Gosselin S, Guimont C, Godwin J, Archam-bault PM, et al. Treatment for calcium channel blocker poi-soning: A systematic review. Clin Toxicol (Phila) 2014; 52(9): 926–44.

Masson R, Colas V, Parienti J, Lehoux P, Massetti M, Charbonneau P, et al. A comparison of survival with and without extracor¬poreal life support treatment for severe poisoning due to drug intoxication. Resuscitation 2012; 83(11): 1413–7.

Radovanović MR, Miletić GM, Radovanović MS. Successful treat-ment of polymedicamentous poisoning with metoprolol, dilti-azem and cilazapril. Vojnosanit Pregl 2009; 66(11): 904–8. (Serbian)

Vuković-Ercegović G, Perković-Vukčević N, Đorđević S, Šegrt Z, Potre¬bić O, Janković SR, et al. Successful usage of intravenous li-pid emulsion in treatment of acuteverapamil poisoning: A case report. Vojnosanit Pregl 2017; 74(3): 278–81.

Daubin C, Lehoux P, Ivascau C, Tasle M, Bousta M, Lepage O, et al. Extracorporeal life support in severe drug intoxication: a ret¬rospective cohort study of seventeen cases. Crit Care 2009; 13(4): R138.

Mégarbane B, Leprince P, Deye N, Résière D, Guerrier G, Rettab S, et al. Emergency feasibility in medical intensive care unit of extracorporeal life support for refractory cardiac arrest. Inten-sive Care Med 2007; 33(5): 758–64.

Babatasi G, Massetti M, Verrier V, Lehoux P, Le Page O, Bruno PG, et al. Severe intoxication with cardiotoxic drugs: Value of emergency percutaneous cardiocirculatory assistance. Arch Mal Coeur Vaiss 2001; 94(12): 1386–92.

Lange DW, Sikma MA, Meulenbelt J. Extracorporeal membrane oxygenation in the treatment of poisoned patients. Clin Toxi-col (Phila) 2013; 51(5): 385–93.

Pozzi M, Koffel C, Djaref C, Grinberg D, Fellahi JL, Hugon-Vallet E, et al. High rate of arterial complications in patients sup-ported with extracorporeal life support for drug intoxication-induced refractory cardiogenic shock or cardiac arrest. J Tho-rac Dis 2017; 9(7): 1988–96.

Lee HM, Archer JR, Dargan PI, Wood DM. What are the adverse effects associated with the combined use of intravenous lipid emulsion and extracorporeal membrane oxygenation in the poisoned patient. Clin Toxicol (Phila) 2015; 53(3): 145–50.

Kolcz J, Pietrzyk J, Januszewska K, Procelewska M, Mroczek T, Malec E. Extracorporeal life support in severe propranolol and vera¬pamil intoxication. J Intensive Care Med 2007; 22(6): 381–5.