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Vol. 78 Br. 5 (2021)
Vol. 78 Br. 5 (2021)

Uticaj dijalizne membrane obložene vitaminom E na oksidacioni stres u toku pojedinačne seanse on-line hemodijafiltracije

DOI: 10.2298/VSP190730097A
Svetlana Antić
Military Medical Academy, Clinic for Nephrology, Belgrade, Serbia
Nevena Draginić
University of Kragujevac, Faculty of Medical Sciencies, Department of Pharmacy, Kragujevac, Serbia
Dejan Pilčević
Military Medical Academy, Clinic for Nephrology, Belgrade, Serbia
Vladimir Živković
University of Kragujevac, Faculty of Medical Sciencies, Department of Physiology, Kragujevac, Serbia
Ivan Srejović
University of Kragujevac, Faculty of Medical Sciencies, Department of Physiology, Kragujevac, Serbia
Nevena Jeremić
University of Kragujevac, Faculty of Medical Sciencies, Department of Pharmacy, Kragujevac, Serbia
Dejan Petrović
University of Kragujevac, Faculty of Medical Sciencies, Department of Internal Medicine, Kragujevac, Serbia
Vladimir Jakovljević
University of Kragujevac, Faculty of Medical Sciencies, Department of Physiology, Kragujevac, Serbia
PDF (engleski)

Objavljeno

2021-05-31

Sekcija

Originalni članak

Sažetak

Uvod/Cilj. Oksidacioni stres je značajan faktor rizika od razvoja kardiovaskularnih aterosklerotskih bolesti u populaciji bolesnika koji se leče redovnom hemodijalizom. Bioinkompatibilnost dijalizne membrane i povećana koncentracija endotoksina u rastvoru za hemodijalizu su dva glavna faktora koja mogu da podstaknu oksidacioni stres. Rad je imao za cilj da ispita uticaj membrane obložene vitaminom E na oksidacioni stres u toku pojedinačne seanse on-line hemodijafiltracije. Metode. Ispitana su 24 bolesnika koja su lečena on-line hemodijafiltracijom sa polisulfonskom dijaliznom membranom obloženom vitaminom E (Leoceed 21H), a zatim i polisulfonskom dijaliznom membranom neobloženom vitaminom E (FX800). Glavni parametri oksidacionog stresa, koji su praćeni, bili su: superoksidni anjon (O2-), vodonik peroksid (H2O2), reaktivne supstancije vezane za tiobarbituričnu kiselinu


(TBARS), azotni oksid (NO2-), katalaza (CAT), superoksid dizmutaza (SOD) i aktivnost redukovanog glutationa (GSH). Za statističku analizu korišćeni su: Kolmogorov-Smirnov test, Student-ov t-test za vezane uzorke i Wilcoxon-ov test. Rezultati. On-line hemodijafiltracija sa high-flux polisulfonskom membranom obloženom vitaminom E statistički je značajno smanjivala koncentraciju TBARS i aktivnost SOD u serumu. Nakon seanse on-line hemodijafiltracije sa high-flux polisulfonskom membranom koja nije bila oboložena vitaminom E statistički se značajno povećala koncentracija H2O2 u serumu, dok se aktivnost SOD značajno smanjila. Kod ostalih ispitivanih parametara oksidacionog stresa nije utvrđena statistički značajna razlika između korišćenih membrane. Zaključak. Pojedinačna seansa on-line hemodijafiltracije sa polisulfonskom membranom obloženom vitaminom E statistički značajno utiče na oksidacioni stres. Koncentracija TBARS u serumu je statistički značajno niž posle pojedinačne seanse on-line hemodijafiltracije sa membranom obloženom vitaminom E. Smanjena aktivnost SOD mogla bi da bude posledica pojačanog gubitka mikroelemanata u toku seanase on-line hemodijafiltracije sa high-flux polisulfonskom membranom. Izbor bolesnika, on-line hemodijafiltracija sa polisulfonskom membranom obloženom vitaminom E kontinuirano u vremenskom periodu od 3–6 meseci i povećanje kapaciteta antioksidacione zaštite mogli bi da smanje rizik od kardiovaskularnog morbiditeta i mortaliteta kod bolesnika na hemodijalizi.

Ključne reči

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DOI: 10.2298/VSP190730097A

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