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Vol. 74 Br. 3 (2017)
Vol. 74 Br. 3 (2017)

Uspešna primena intravenskih emulzija masti u terapiji akutnog trovanja verapamilom

DOI: 10.2298/VSP150901010V
Gordana N Vuković Ercegović
Nacionalni centar za kontrolu trovanja, Klinika za urgentnu i kliničku toksikologiju, Vojnomedicinska akademija, Beograd
Nataša Perković Vukčević
National Poison Control Center, Military Medical Academy, Belgrade, Serbia
Snežana Djordjević
National Poison Control Center, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia
Zoran Šegrt
Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia
Olivera Potrebić
National Poison Control Center, ilitary Medical Academy, Belgrade, Serbia
Snežana R Janković
Institute for Scientific Information, Military Medical Academy, Belgrade, Serbia
Jasmina Jović Stošić
National Poison Control Center, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia
Nadica Marinković
Institute of Pathology and Forensic Medicine, Military Medical Academy, Belgrade, Serbia; Faculty of Medicine of the Military Medical Academy, University of Defence, Belgrade, Serbia

Sažetak

Uvod. Poslednjih godina intravenske emulzije masti uspešno se koriste u terapiji akutnih trovanja lipofilnim supstancama, uključujući i verapamil. Prikaz bolesnika. Prikazana je 37-godišnja pacijentkinja primljena jedan sat nakon ingestije 2,8 g verapamila. Na prijemu je bila hipotenzivna, sa kompletnim srčanim blokom. Zbog izostanka efekta primenjene standardne terapije i daljeg pogoršanja stanja pacijentkinje primenjen je Intralipid® 20%, nakon čega je uspostavljen sinusni ritam. Zabeležen je porast arterijskog pritiska, uz smanjenje koncentracije verapamila, kako ukupnog, tako i slobodne frakcije leka. Zaključak. Intravenske emulzije masti mogu zauzeti važno mesto u terapiji teške akutne intoksikacije i kardiotoksičnosti uzrokovane verapamilom.

Ključne reči

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DOI: 10.2298/VSP150901010V

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