Scindeks Asistent Scindeks Asistent — sistem za ozbiljne časopise i one koji to žele da postanu
Vol. 70 Br. 5 (2013)
Vol. 70 Br. 5 (2013)

Zuklopentiksol dekanoat u trudnoći: uspešan ishod dve uzastopne trudnoće iste majke

DOI: 10.2298/1502
Vladimir Janjić
Psychiatry Clinic, Clinical Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Dragan R. Milovanović
Department of Pharmacology and Toxicology, Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Dejana Ružić Zečević
Department of Pharmacology and Toxicology, Clinical Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Dragan Lončar
Gynecology and Obstetrics Clinic, Clinical Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Olivera Laban
Gynecology and Obstetrics Clinic, Clinical Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Marija Stepanović
Department of Pharmacology and Toxicology, Clinical Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Mirjana Varjačić
Gynecology and Obstetrics Clinic, Clinical Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Slobodan Obradović
Pediatric Clinic, Clinical Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Slavica Djukić Dejanović
Psychiatry Clinic, Clinical Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia
Slobodan Janković
Department of Pharmacology and Toxicology, Clinical Centre ”Kragujevac“ and Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia

Dodatni fajlovi

Covering Letter (engleski)

Objavljeno

2017-01-10

Sekcija

Prikaz bolesnika

Sažetak

Uvod. S obzirom na to da ne postoje ili su podaci o ishodu trudnoće u slučaju njihovog korišćenja oskudni, skoro svi antipsihotici su svrstani u kategoriju sa srednjim rizikom u slučaju trudnoće. Prikazano je korišćenje zuklopentiksol-dekanoata u dve uzastopne trudnoće iste žene, što do sada nije bilo objavljeno u dostupnoj recenziranoj literaturi. Prikaz bolesnika. Žena srednjih godina koja je bolovala od šizofrenije primala je injekciju zuklopentiksol-dekanoata tokom svoje dve uzastopne trudnoće. Oko četiri i po meseca pre dijagnoze prve trudnoće (~3,5 godine posle početka psihoze) u terapijski protokol je uveden zuklopentiksol-dekanoat (400 mg svake druge nedelje, i.m. injekcija) zbog prethodnog neredovnog uzimanja haloperidola i risperidona. Postignuto je značajno kliničko poboljšanje, pa je doza leka tokom trudnoća snižena na 200 mg jednom mesečno i održavana do sada. U obe trudnoće rođena je po jedna zdrava devojčica i normalno su se razvijale do uzrasta od šest meseci, odnosno 3,5 godine. Tokom trudnoća i posle rođenja dece psihijatrijski status i socijalno funkcionisanje majke bili su značajno poboljšani i do danas stabilni. Pomno praćenje zdravstvenog stanja majke, multidisciplinarni pristup njenom lečenju i praćenju trudnoća kao i potpuna komplijansa sa propisanim medikamentnim protokolom najverovatnije su bili presudni za terapijski uspeh. Zaključak. Povoljni ishodi prikazane bolesnice ukazuju da je kod trudnica obolelih od psihoze zuklopentiksol-dekanoat racionalna terapijska opcija, kada očekivana korist prevazilazi potencijalne rizik, ali su za definitivan dokaz o njegovoj bezbednosti potrebne kontrolisane studije sa velikim uzorkom.

Ključne reči

Array
Array
Array
Array
Array
Array
Array
Array
Array
Array
Array
DOI: 10.2298/1502

Reference

Howard LM. Fertility and pregnancy in women with psychotic disorders. Eur J Obstet Gynecol Reprod Biol 2005; 119(1): 3−10.

Seeman MV. Gender differences in the prescribing of antipsy-chotic drugs. Am J Psychiatry 2004; 161(8): 1324−33.

Newport DJ, Calamaras MR, DeVane CL, Donovan J, Beach AJ, Winn S, et al. Atypical antipsychotic administration during late pregnancy: placental passage and obstetrical outcomes. Am J Psychiatry 2007; 164(8): 1214−20.

Trixler M, Gáti A, Fekete S, Tényi T. Use of antipsychotics in the management of schizophrenia during pregnancy. Drugs 2005; 65(9): 1193−206.

Kennedy D. Antipsychotic drugs in pregnancy and breastfeed-ing. Aust Prescr 2007; 30(6): 162−3.

Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lacta-tion. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2008.

Sweetman SC, Blake PS, McGlashan JM, Parsons AV. Anxiolytic Sedatives Hypnotics and Antipsychotics. In: Sweetman SC, edi-tor. Martindale, the complete drug reference. 33rd ed. London: Pharmaceutical Press; 2002. p. 714.

Clopixol Depot. Auckland: Drugsite Trust; 2011. Available from: http://www.drugs.com/international/clopixol-depot.html.

Antipsychotic depot injections: British National Formulary. London: BMJ Gropup and RPS Publishing; 2009. p. 202−4.

Leucht C, Heres S, Kane JM, Kissling W, Davis JM, Leucht S. Oral versus depot antipsychotic drugs for schizophrenia-a critical systematic review and meta-analysis of randomised long-term trials. Schizophr Res 2011; 127(1−3): 83−92.

Haloperidol Decanoate Injection: Current Drug Shortages. Sil-ver Spring, Food and Drug Administration, 2011. Available from: http:// www.fda.gov/ Drugs/ DrugSafety/ DrugShortages/ ucm050792.htm. [cited 2011 October 5].

Kim SW, Kim KM, Kim JM, Shin IS, Shin HY, Yang SJ, et al. Use of long-acting injectable risperidone before and throughout pregnancy in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(2): 543−5.

Handal M, Matheson I, Bechensteen AG, Lindemann R. Antipsy-chotic agents and pregnant women. A case report. Tidsskr Nor Laegeforen 1995; 115(20): 2539−40. (Norwegian)

American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics 2001; 108(3): 776−89.

Galbally M, Snellen M, Walker S, Permezel M. Management of an-tipsychotic and mood stabilizer medication in pregnancy: rec-ommendations for antenatal care. Aust N Z J Psychiatry 2010; 44(2): 99−108.

McCauley-Elsom K, Gurvich C, Elsom SJ, Kulkarni J. Antipsychot-ics in pregnancy. J Psychiatr Ment Health Nurs 2010; 17(2): 97−104.

Preuzimanja

Podaci o preuzimanju još nisu dostupni.